Palladium-catalyzed direct functionalization of imidazolinone: synthesis of dibromophakellstatin.
نویسندگان
چکیده
We have examined the direct arylation of imidazolinone (1) with 6 different palladium sources, 15 different phosphine ligands, 12 different bases and 14 different solvent systems. There is no significant difference between using Pd(OAc)2 and Pd(TFA)2. This reaction proceeds less efficiently or reproducibly with Pd2(dba)3/(o-biphenyl)PCy2, O=PCy3, O=PPh3, P(OMe)3, PCy3·HBF4, PCy3, PPBu /DMF, NMP/Na CO . 3 2 3
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 129 25 شماره
صفحات -
تاریخ انتشار 2007